Hmga2 is a driver of tumor metastasis diagnosis

The lung has been the most common extrauterine site for leiomyoma metastasis and if pulmonary symptoms develop or there is an increasing growth interval, surgical intervention is required. We performed a metaanalysis to determine the clinicpathological and prognostic value of hmga2 overexpression in different human tumors. However, the mechanisms of metastasis in pancreatic cancer remain unclear. These contrast with benign tumors, which do not spread. P53induced mir1249 inhibits tumor growth, metastasis. Frontiers the role of lncrnas in the distant metastasis. Hmga2 is aberrantly regulated in several human tumors. However, little is known regarding in vivo modulation of hmga2 and its effector functions in tumor metastasis. Here, we report the identification of the minor groove dnabinding factor high mobility group. However, high hmga2 expression levels have been found in a variety of benign and malignant tumors 12. Thus, hmga2 remains a prognostic marker which identifies a metastatic cancer cell state in primary pdac, however hmga2 has limited if any direct functional impact on pdac progression and therapy resistance. Ectopic expression of hmga2 in epithelial cells induces epithelialmesenchymal transition emt, which has been implicated in the acquisition of metastatic.

The effects of hmga2 on tumor cell behavior, such as. Hmga2 is a driver of tumor metastasis cancer research. A major obstacle for effective cancer treatment by radiation therapy is. Therefore, hmga2 can be considered a driver of the emt and metastasis, and delineation of the hmga2 pathway will potentially define a series of genes specific for invasion and metastasis of epithelial cancer cells. Hmga2 regulates lung cancer proliferation and metastasis. Prognostic value of high mobility group protein a2 hmga2. Metastasis is one of the main reasons for treatment failure in.

Therefore, hmga2 can be considered a driver of the emt and metastasis and delineation of the hmga2 pathway will potentially define a series of genes specific for invasion and metastasis of epithelial cancer cells. Ectopic expression of hmga2 in epithelial cells induces epithelialmesenchymal transition emt, which has been implicated in the acquisition of metastatic characters in tumor cells. Pdf overexpression of hmga2 promotes metastasis and. Pelp, a nuclear receptor coregulator, was also found to regulate emt and bc. Expression of hmga2 may be related to dukes stage, tumor grade piscuoglio et al. Although some types of metastatic cancer can be cured with current treatments, most cannot. Metastasis to long distance organs is the main reason leading to morality of tongue squamous cell carcinoma tscc. Downregulating hmga2 attenuates epithelialmesenchymal. Expression of hmga 2 in bladder cancer and its association with. Hmga2 is dispensable for pancreatic cancer development. Breast cancer bc remains the most frequently diagnosed cancer worldwide. Morishita a1, zaidi mr, mitoro a, sankarasharma d, szabolcs m, okada y, darmiento j, chada k. Treatment of mice with hmga2wildtype and hmga2deficient tumours.

On the other hand, in the early stages of metastasis. Olr1 promotes pancreatic cancer metastasis via increased c. Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Consistent with the effect of let7a mimics, knockdown of hmga2 also suppressed emt. Oncogenic nras, required for pathogenesis of embryonic. Increasing evidences have recognized that the epithelial to mesenchymal transition emt, a driver of invasion and metastasis of cancer, may play a pivotal role in multiple types of tumor cell metastatic dissemination by endowing cells with a more motile, invasive potential 811. However, the mechanisms of regulation involving these drivers are poorly explored. In order to find new tools to make diagnosis of epithelial ovarian cancer eoc at. P53induced mir1249 inhibits tumor growth, metastasis, and angiogenesis by targeting vegfa and hmga2 skip to main content thank you for visiting. Hmga1 and hmga2 overlap in their expression in both human and murine pdac, however knockdown of hmga1 in hmga2deficient cancer cells also did not decrease metastatic ability.

Embryonic rhabdomyosarcoma erms is the most common softtissue tumor in children. Hmga2 is involved in a number of different processes, from cellular proliferation to epithelial. A novel truncated form of hmga2 in tumors of the ovaries. Hmga2 was upregulated in npc cell lines and clinical specimens p invasion. On the one hand, it reduces tumor necrosis induced by hypoxia, inhibits the infiltration of inflammatory cells, and thus inhibits tumor metastasis. Uterine intravenous leiomyomatosis with an isolated large. In tumour treatment, hmga2 protects tumour cells from. Among breast cancer patients, distant metastasis and invasion is the leading cause of bc related death. Pancreatic cancer is one of the most lethal human malignancies, partly because of its propensity for metastasis. Tumor suppressor ngx6 inhibits the growth and metastasis.

The risk of breast cancer in women increases with age, and this is partly attributable to the accumulation of genetic lesions. High mobility group protein a2 hmga2 is a transcription factor that plays an important role in the invasion and metastasis of gastric carcinoma gc. Overexpression of hmga2 is correlated with a higher risk of metastasis and an unfavorable prognosis in patients with cancer. Hmga2 is a driver of tumor metastasis asahiro morishita1, m. Lung cancer is the leading cause of cancer death in both men and women in the united states, accounting for approximately 30% of cancer. Detection of high mobility group a2 specific mrna in the plasma of. Raza zaidi 3, akira mitoro, devipriya sankarasharma, matthias szabolcs2, yasunori okada4, jeanine darmiento1, and kiran chada3 abstract the nonhistone chromatinbindingprotein hmga2 isexpressed predominantly in the mesenchyme before its. The goal of these treatments is to stop or slow the growth of the cancer or to relieve symptoms caused by it. Metastasis is a pathogenic agents spread from an initial or primary site to a different or secondary site within the hosts body. Overexpression of hmga2 promotes tongue cancer metastasis. Breast cancer is the most common malignancy in women worldwide. Even so, there are treatments for all patients with metastatic cancer. Hmga2 regulates transcription of the imp2 gene via an intronic.